Drugs (Pharma Research)

Name: Tafenoquine Synonym: Etaquine, Krintafel, Arakoda, WR238605 Chemical formula: C 24 H 28 F 3 N 3 O 3 Molecular weight: 463.501 IUPAC name: N4-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine SMILES: COC1=CC(C)=C2C(OC3=CC=CC(=C3)C(F)(F)F)=C(OC)C=C(NC(C)CCCN)C2=N1 Indication: Tafenoquine is used for the treatment and prevention of relapsed infection caused by Plasmodium vivax in patients of age 16 years and above. Developmental stage: Phase III studies, developing as a single-dose treatment. Approved by US FDA July 2018 and by Australian TGA September 2018. Approved in first malaria-endemic country (Brazil) in October 2019 and in Thailand in December 2019 Under review in 5 endemic countries (MMV, Medicines for malaria venture). Company: GlaxoSmithKline; MMV About Plasmodium vivax malaria: Malaria caused by P. vivax have a significant impact on the health and economy of the population of South-Asia, South-East ...

Clinical trials to findout what can work against coronavirus (part 1) According to an article published in The Times of India, dated March 30 th , 2020, BCG or the bacillus Calmette-Guerin vaccine that has been used for ages to immunize new-borns to protect against tuberculosis, is being given to health-care workers in Melbourne to see if it can protect them against the deadly coronavirus. BCG, in addition to prevention against tuberculosis, has off-target benefits as well. It is a common immunotherapy for early-stage bladder cancer; it also seems to boost body’s immune system to fight infections better. The study reported is led by Nigel Curtis, at Murdoch Children’s Research Institute in Melbourne. According to him, BCG vaccine can boost the immune system and defend better against a range of viruses and bacteria. 4000 health care workers have volunteered to participate in a six-month trial to be vaccinated against seasonal influenza and TB, or the flu shot only. A placebo ...