Drugs (Pharma Research)

  Name: Atovaquone Synonym: Mepron, Wellvone, Acuvel Chemical formula: C 22 H 19 ClO 3 Molecular weight: 366.8 g/mol IUPAC name: 2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione SMILES: OC1=C([C@H]2CC[C@@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=CC=CC=C2C1=O Indication:   It has antiprotozoal, antimicrobial and antipneumocystis activity and thus used for the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole. Developmental stage: In combination with proguanil, it is available commercially as Malarone and used for the prevention and treatment of malaria caused by Plasmodium falciparum . Company: GlaxoSmithKline Description: Atovaquone or 2-(trans-4-(p-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone, is a hydroxynaphthoquinone analog of ubiquinone and an inhibitor of cytochrome bc 1 complex ( Mather et al., 2005) . It is found to be well tolerated, metab...

Name: Tafenoquine Synonym: Etaquine, Krintafel, Arakoda, WR238605 Chemical formula: C 24 H 28 F 3 N 3 O 3 Molecular weight: 463.501 IUPAC name: N4-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine SMILES: COC1=CC(C)=C2C(OC3=CC=CC(=C3)C(F)(F)F)=C(OC)C=C(NC(C)CCCN)C2=N1 Indication: Tafenoquine is used for the treatment and prevention of relapsed infection caused by Plasmodium vivax in patients of age 16 years and above. Developmental stage: Phase III studies, developing as a single-dose treatment. Approved by US FDA July 2018 and by Australian TGA September 2018. Approved in first malaria-endemic country (Brazil) in October 2019 and in Thailand in December 2019 Under review in 5 endemic countries (MMV, Medicines for malaria venture). Company: GlaxoSmithKline; MMV About Plasmodium vivax malaria: Malaria caused by P. vivax have a significant impact on the health and economy of the population of South-Asia, South-East ...