Drugs (Pharma Research)

I UPAC name: 2-Amino-1-(2-(4-fluorophenyl)-3-((4-fluorophenyl)amino)-5,6-dihydro-8,8-dimethylimidazo(1,2-a)pyrazin-7(8H)-yl)ethanone   Molecular formula: C22H23F2N5O Molecular weight: 411.4 g/mol Synonyms: Ganaplacide, KAF-156, GNF-156, GNF 156 SMILES: CC1(C2=NC(=C(N2CCN1C(=O)CN)NC3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C Developmental Status: Phase IIb combination study ongoing Company: Discovery partnership between MMV, Wellcome Trust, Novartis, and the Swiss Tropical and Public Health Institute Description: The imidazolopiperazine compound KAF156 belongs to a new class of antimalarial agents with activity against asexual and sexual blood stages and the pre-erythrocytic liver stages of malarial parasites. According to studies, KAF156 displayed activity against vivax and falciparum malaria, including artemisinin-resistant parasites. (White, N.J. et al., 2016). Mechanism of action: The mechanism of action of KAF156 could not yet be determined. Decreased susceptibility to KAF156...

  Name: Atovaquone Synonym: Mepron, Wellvone, Acuvel Chemical formula: C 22 H 19 ClO 3 Molecular weight: 366.8 g/mol IUPAC name: 2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione SMILES: OC1=C([C@H]2CC[C@@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=CC=CC=C2C1=O Indication:   It has antiprotozoal, antimicrobial and antipneumocystis activity and thus used for the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole. Developmental stage: In combination with proguanil, it is available commercially as Malarone and used for the prevention and treatment of malaria caused by Plasmodium falciparum . Company: GlaxoSmithKline Description: Atovaquone or 2-(trans-4-(p-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone, is a hydroxynaphthoquinone analog of ubiquinone and an inhibitor of cytochrome bc 1 complex ( Mather et al., 2005) . It is found to be well tolerated, metab...