ATOVAQUONE
Name: Atovaquone Synonym: Mepron, Wellvone, Acuvel Chemical formula: C 22 H 19 ClO 3 Molecular weight: 366.8 g/mol IUPAC name: 2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione SMILES: OC1=C([C@H]2CC[C@@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=CC=CC=C2C1=O Indication: It has antiprotozoal, antimicrobial and antipneumocystis activity and thus used for the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole. Developmental stage: In combination with proguanil, it is available commercially as Malarone and used for the prevention and treatment of malaria caused by Plasmodium falciparum . Company: GlaxoSmithKline Description: Atovaquone or 2-(trans-4-(p-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone, is a hydroxynaphthoquinone analog of ubiquinone and an inhibitor of cytochrome bc 1 complex ( Mather et al., 2005) . It is found to be well tolerated, metab...